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Lupine products are proudly built in Conway, NH. The components (hardware, thread, webbing, etc.) are from a mix of domestic and international sources. Lupine products proudly guarantees their products(Even if Chewed)®, not guaranteed-not-to-be-chewed. Nylon webbing is extremely strong, but, like all fabrics, its chew resistance is quite low. The jacquard webbing they use is woven. Remember those potholders you made at camp? Up-and-down, back-and-forth ... Lupine webbing is made much the same way. There's a grid of thread loops that makes webbing very strong and durable.
Based in Conway, New Hampshire, Lupine is committed to your pets. All patterns are made using threads which are dyed prior to weaving. Bleeding is very uncommon, but could happen, especially in response to whitening shampoos, flea products, and other topical products. Machine-washing products is fine. Some people use a mesh bag (to save wear-and-tear on the inside of the tub), others just put them in with jeans and similar sturdy clothes. The key points are warm, not hot water; mild soap, no bleach; and air dry only - don't put them in the dryer or the nylon may get all shriveled! For extreme situations, pre-soaking in an enzymatic cleaner like Nature's Miracle or Simple Solution may be helpful. If bad dog-smell is an ongoing problem, consult your vet. It may indicate a health issue or the need for a change in diet.